Medications


Semaglutide oral tablets

What is this medicine?

SEMAGLUTIDE (Sem a GLOO tide) is used to improve blood sugar control in adults with type 2 diabetes. This medicine may be used with other diabetes medicines.

How should I use this medicine?

Take this medicine by mouth with a glass of plain water that is less than 4 ounces (less than 120 mL). Follow the directions on the prescription label. Do not cut, crush or chew this medicine. Swallow the tablets whole. Take at least 30 minutes before the first food, other beverage, or other oral medications of the day. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • changes in vision

  • diarrhea that continues or is severe

  • lump or swelling on the neck

  • severe nausea

  • signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine

  • signs and symptoms of low blood sugar such as feeling anxious, confusion, dizziness, increased hunger, unusually weak or tired, sweating, shakiness, cold, irritable, headache, blurred vision, fast heartbeat, loss of consciousness

  • signs and symptoms of kidney injury like trouble passing urine or change in the amount of urine

  • trouble swallowing

  • unusual stomach upset or pain

  • vomiting

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

  • constipation

  • diarrhea

  • nausea

  • stomach upset

What may interact with this medicine?

What may interact with this medicine?

  • aminophylline

  • carbamazepine

  • cyclosporine

  • digoxin

  • levothyroxine

  • other medicines for diabetes

  • phenytoin

  • tacrolimus

  • theophylline

  • warfarin

Many medications may cause changes in blood sugar, these include:

  • alcohol containing beverages

  • antiviral medicines for HIV or AIDS

  • aspirin and aspirin-like drugs

  • certain medicines for blood pressure, heart disease, irregular heart beat

  • chromium

  • diuretics

  • female hormones, such as estrogens or progestins, birth control pills

  • fenofibrate

  • gemfibrozil

  • isoniazid

  • lanreotide

  • male hormones or anabolic steroids

  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate

  • medicines for weight loss

  • medicines for allergies, asthma, cold, or cough

  • medicines for depression, anxiety, or psychotic disturbances

  • niacin

  • nicotine

  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen

  • octreotide

  • pasireotide

  • pentamidine

  • phenytoin

  • probenecid

  • quinolone antibiotics such as ciprofloxacin, levofloxacin, ofloxacin

  • some herbal dietary supplements

  • steroid medicines such as prednisone or cortisone

  • sulfamethoxazole; trimethoprim

  • thyroid hormones

Some medications can hide the warning symptoms of low blood sugar (hypoglycemia). You may need to monitor your blood sugar more closely if you are taking one of these medications. These include:

  • beta-blockers, often used for high blood pressure or heart problems (examples include atenolol, metoprolol, propranolol)

  • clonidine

  • guanethidine

  • reserpine

What if I miss a dose?

If you miss a dose, skip it. Take your next dose at the normal time. Do not take extra or 2 doses at the same time to make up for the missed dose.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep this medicine in the original blister card until use. Keep in a dry place. Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • endocrine tumors (MEN 2) or if someone in your family had these tumors

  • eye disease, vision problems

  • history of pancreatitis

  • kidney disease

  • stomach problems

  • thyroid cancer or if someone in your family had thyroid cancer

  • an unusual or allergic reaction to semaglutide, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress.

Drink plenty of fluids while taking this medicine. Check with your doctor or health care professional if you get an attack of severe diarrhea, nausea, and vomiting. The loss of too much body fluid can make it dangerous for you to take this medicine.

A test called the HbA1C (A1C) will be monitored. This is a simple blood test. It measures your blood sugar control over the last 2 to 3 months. You will receive this test every 3 to 6 months.

Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.

Always carry a quick-source of sugar with you in case you have symptoms of low blood sugar. Examples include hard sugar candy or glucose tablets. Make sure others know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, such as seizures or unconsciousness. They must get medical help at once.

Tell your doctor or health care professional if you have high blood sugar. You might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine.

Do not skip meals. Ask your doctor or health care professional if you should avoid alcohol. Many nonprescription cough and cold products contain sugar or alcohol. These can affect blood sugar.

Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2020 Elsevier
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